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ORIGINAL ARTICLE
Year : 2022  |  Volume : 11  |  Issue : 2  |  Page : 50-55

Evaluation of clinical and biochemical parameters of trinidadian patients with coronary artery disease for predicting the revascularization strategy


1 Department of Pre-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Trinidad
2 Multidisciplinary Research Unit, Shimoga Institute of Medical Sciences, Shivamogga, Karnataka, India
3 Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, Trinidad
4 Department of Biochemistry; Department of Research, Panimalar Medical College Hospital and Research Institute, Varadharajapuram, Poonamallee, Chennai, Tamil Nadu, India
5 Department of Research, Panimalar Medical College Hospital and Research Institute, Varadharajapuram, Poonamallee, Chennai, Tamil Nadu, India

Correspondence Address:
PhD, DSc B Shivananda Nayak
Msc, PhD, NRCC-CC, PGDCHC, Department of Preclinical Sciences, Faculty of Medical Sciences, The University of The West Indies
Trinidad
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcpc.jcpc_46_21

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Background: In recent times, optimal revascularization approaches have been used for treating multi-vessel obstructive coronary artery disease (CAD) patients. Based on the disease severity, making the decision to perform a suitable revascularization intervention in the patients is of paramount importance. Aim: This study aimed to evaluate the biochemical parameters of patients with suspected CAD in Trinidad and assess their clinical significance for predicting revascularization strategy. Materials and Methods: One hundred and twenty-four patients referred for angiography were recruited for the study. Biochemical parameters such as fasting blood sugar (FBS), lipid profile, cardiac enzymes, creatinine, uric acid, N-terminal probrain natriuretic peptide (NT-proBNP), soluble ST2, interleukin 6, and hemoglobin A1C (HbA1c) were explored. Similarly, we examined clinical parameters such as age, the presence of chronic conditions, and ethnicity. Results: With respect to revascularization strategies, FBS, NT-proBNP, HbA1c, and soluble ST2 correlated moderately with coronary artery bypass grafting (CABG) by Point-Biserial correlations: FBS-r = 0.196, P = 0.029, NT-proBNP-r = 0.208, P = 0.020, soluble ST2-r = 0.178, P = 0.048, and HbA1c-r = 0.282, P = 0.001. The presence of Type 2 diabetes (T2D) at baseline and ethnicity also formed statistically significant associations with CABG-ethnicity (χ2 (1) =7.267, P = 0.007) and T2D at baseline (χ2 (1) =12.858, P < 0.001). Conclusion: Ethnicity and presence of T2D were also significantly associated with both CAD severity and revascularization decision-making and should be taken into consideration for further study. Further investigation of these parameters might prove to be useful to predict the revascularization strategy required for treating CAD patients.


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