Journal of Clinical and Preventive Cardiology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 7  |  Issue : 1  |  Page : 17--21

Effect of ranolazine on improvement of left ventricular dysfunction in patients with chronic stable angina: A randomized controlled clinical trial


C R Madhu Prabhu Doss1, Melvin George2, Amrita Jena2, Varsha Srivatsan2, Aruna Sridhar2, VE Dhandapani1 
1 Department of Cardiology, SRM Medical College Hospital and Research Centre, Kancheepuram, Tamil Nadu, India
2 Department of Clinical Pharmacology, SRM Medical College Hospital and Research Centre, Kancheepuram, Tamil Nadu, India

Correspondence Address:
Dr. Melvin George
Department of Clinical Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram - 603 203, Tamil Nadu
India

Objectives: To study the effect of ranolazine on improvement of left ventricular (LV) dysfunction in comparison to trimetazidine in patients with chronic stable angina (CSA). Ranolazine is an anti-anginal agent that acts on the late inward sodium current and prevents pathologic intracellular calcium accumulation that leads to ischemia, myocardial dysfunction, and electrical instability. Methodology: After screening and obtaining informed consent, 29 patients with CSA who have sustained ST-Elevation Myocardial Infarction more than 12 weeks ago with LV ejection fraction (LVEF) ≤40% in a 2:1 ratio to receive ranolazine 500 mg BD (n = 19) or trimetazidine 35 mg BD (n = 10) were enrolled in the study. The patients were evaluated at the end of 8 weeks for the improvement in LV dysfunction by transthoracic echocardiography. Results: No significant difference was found in the baseline characteristics of the patients between the two groups except the increased body mass index among users of trimetazidine (26.3 ± 5.07 vs. 22.1 ± 3.26, P = 0.03). Study patients receiving ranolazine 500 mg BD for 8 weeks significantly improved the LVEF. No improvement was seen in diastolic function. Ranolazine was well tolerated among the patients. Conclusion: Ranolazine at a dose of 500 mg BD given for 8 weeks helps in improving the LVEF in patients with CSA and is a suitable option than trimetazidine among patients with CSA.


How to cite this article:
Prabhu Doss C R, George M, Jena A, Srivatsan V, Sridhar A, Dhandapani V E. Effect of ranolazine on improvement of left ventricular dysfunction in patients with chronic stable angina: A randomized controlled clinical trial.J Clin Prev Cardiol 2018;7:17-21


How to cite this URL:
Prabhu Doss C R, George M, Jena A, Srivatsan V, Sridhar A, Dhandapani V E. Effect of ranolazine on improvement of left ventricular dysfunction in patients with chronic stable angina: A randomized controlled clinical trial. J Clin Prev Cardiol [serial online] 2018 [cited 2022 May 22 ];7:17-21
Available from: https://www.jcpconline.org/article.asp?issn=2250-3528;year=2018;volume=7;issue=1;spage=17;epage=21;aulast=Prabhu;type=0