Journal of Clinical and Preventive Cardiology

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 10  |  Issue : 3  |  Page : 106--111

Comparison of global registry of acute coronary events and thrombolysis in myocardial infarction risk scores in non-ST-elevation acute coronary syndrome


Satyanarayan Routray, Chhabi Satpathy, Nirmal Kumar Mohanty, Bijay Kumar Dash, Rajendra Prasad Satapathy 
 Department of Cardiology, SCB Medical College and Hospital, Cuttack, Odisha, India

Correspondence Address:
Dr. Rajendra Prasad Satapathy
Room No-100, SR Hostel, SCB Medical College and Hospital, Cuttack, Odisha
India

Context: The Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) scores in predicting coronary disease severity in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) have not been proved. Aims: We aimed to compare the GRACE score with TIMI risk score for prediction of the angiographic severity of coronary artery disease (CAD) in patients with NSTE-ACS. Settings and Design: This was an observational cross-sectional study. Subjects and Methods: Total 202 NSTE-ACS (NSTE myocardial infarction and unstable angina) patients were included. The GRACE and TIMI scores were estimated. Coronary angiogram was done and the Gensini score and vessel score were used to assess the severity of CAD. Statistical Analysis Used: SPSS software version 27.0 was used for statistical analysis. For comparison of two means, independent sample t-test/Mann–Whitney U-test was used, while for more than two means, one-way ANOVA/Kruskal–Wallis test was used. The receiver operating characteristic (ROC) curve was applied for the predictability of GRACE and TIMI scores for severity of disease. Results: A positive association between the Gensini score and vessel score was observed with both the GRACE (P = 0.001) and TIMI (P = 0.001) scores. The area under the ROC curve for the GRACE score was 0.765 (95% confidence interval [CI] = 0.676–0.854), significantly superior to the area under the ROC curve of the TIMI score (0.715; 95% CI = 0.618–0.812). Risk factors such as higher age, hypertension, smoking history, dyslipidemia, ECG changes such as ST deviation and T inversion, and Killip classification showed a statistically significant association with severity of disease. Conclusions: Both the GRACE and TIMI risk scores were a good predictor of angiographic severity of CAD in patients with NSTE-ACS, and the GRACE score was found to be superior to the TIMI risk score.


How to cite this article:
Routray S, Satpathy C, Mohanty NK, Dash BK, Satapathy RP. Comparison of global registry of acute coronary events and thrombolysis in myocardial infarction risk scores in non-ST-elevation acute coronary syndrome.J Clin Prev Cardiol 2021;10:106-111


How to cite this URL:
Routray S, Satpathy C, Mohanty NK, Dash BK, Satapathy RP. Comparison of global registry of acute coronary events and thrombolysis in myocardial infarction risk scores in non-ST-elevation acute coronary syndrome. J Clin Prev Cardiol [serial online] 2021 [cited 2022 Jan 27 ];10:106-111
Available from: https://www.jcpconline.org/article.asp?issn=2250-3528;year=2021;volume=10;issue=3;spage=106;epage=111;aulast=Routray;type=0